An interesting new study published in September 2012 reports that resveratrol moderates hormone secretion from fat cells. Resveratrol is a potent antioxidant found in high concentrations in the skin of red and purple grapes.
Researchers evaluated the impact on white adipose tissue by resveratrol, due to its ability to mimic the beneficial effects of calorie restriction. White adipose tissue is used to store energy in the body. It also acts as a thermal insulator and works to regulate body temperature.
Investigators incubated mature human adipocytes with resveratrol to determine if resveratrol moderates the secretion profile from fat cells. The researchers found that resveratrol administration resulted in increased breakdown of fat, based on a greater amount of sugar released from the cells, as well as reduced intracellular triglyceride content.
Resveratrol treatment also induced secretion of proteins protective against cellular stress and proteins involved in the regulation of cell death. Additionally, the researchers found that resveratrol increased the amount of adiponectin, a protein associated with a lower risk of diabetes, and apolipoprotein E (ApoE), an apolipoprotein required for the normal breakdown of triglyceride-rich lipoprotein constituents.
Plus, resveratrol treatment decreased the amount of plasminogen activator inhibitor-1 (PAI-1), a protein found elevated in conditions such as obesity and the metabolic syndrome and is associated with thrombosis and atherosclerosis. It also reduced the amount of pigment epithelium-derived factor (PEDF), which may improve anti-inflammatory processes and increase insulin sensitivity.
The researchers stated, “These effects may contribute to alleviate obesity-induced metabolic complications. In addition, two novel resveratrol-regulated adipocyte-secreted proteins were identified.”
Rosenow A, et al. J Proteome Res. 2012;9:4733-43.