Single dose of antibiotic therapy can cause long-term gut damage

The statistics are sobering: in the United States alone, antibiotic-resistant bacteria cause 23,000 fatalities and at least 2 million new cases of disease annually. But if you think antibiotic resistance only comes about with massive and repeated rounds of antibiotics, think again.

Science shows that just one dose of antibiotic ‘therapy’ not only contributes to antibiotic resistance, but also brings about long-term damage to the microbes living in the gut. Many of the intestinal bacteria destroyed by antibiotics play a significant role in the body’s natural defense system against cancer and other disease conditions.

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Just one dose: Science reveals the true danger of antibiotics inside the gut

European researchers recently reported study results showing even a single course of antibiotics is capable of disrupting the healthy population of microorganisms in the gut. Just as disturbing, the results can last up to a year and contribute to antibiotic resistance.

In their study, 66 healthy adults from the United Kingdom and Sweden were randomly assigned to receive a full course of one of four antibiotics – ciprofloxacin, clindamycin, amoxicillin or minocycline – or a placebo. The researchers did not know which antibiotic any given participant took throughout the course of the study.

Fecal and saliva samples were collected from the subjects at the start of the study, then again immediately after beginning the study drugs. Additional samples were taken at one, two, four and 12-month intervals after finishing a single course of antibiotics.  Results showed the drugs caused a notable increase in genes associated with antibiotic resistance, while seriously impacting the diversity of microbes in the gut and causing changes still evident months after initial exposure.

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All antibiotics are NOT created equal and the results can be devastating

Researchers have reported differences among the various antibiotics utilized in the study. Specifically, the health-related bacteria in the gut were significantly reduced for up to four months in participants taking clindamycin and up to 12 months in those taking ciprofloxacin. Amoxicillin showed a less dramatic shift in microbial populations, but was the largest contributor to increased antibiotic resistance.

Researchers noted that participants from the UK came into the study with more antibiotic resistance than did the subjects from Sweden. This could be due to cultural differences and the significant decline in antibiotic use in Sweden over the past 15 or 20 years.

Lead author Egija Zaura, PhD, an associate professor in oral microbial ecology at the Academic Centre for Dentistry in Amsterdam, the Netherlands, wrote that microorganisms in study participants’ feces were severely affected by most of the antibiotics, with changes lasting for months. More specifically, researchers reported a decrease in the number of desirable microbes that produce butyrate – which inhibits inflammation, combats cancer and reduces stress in the gut.

Lifesaving question: How do antibiotics increase the risk of disease?

While antibiotic resistance may be at the center of the research results, the affects on microbial populations in the gut have other far-reaching impacts. Earlier research has shown that antibiotics can alter critical gut microbiota that affect the body’s vulnerability to contracting a number of infectious diseases.

These differences in intestinal flora may have a much greater influence on overall health and wellbeing. For example, did you know that changes in the gut’s microbe population can leave the body vulnerable to vitamin and mineral deficiencies, obesity, inflammation of the gut, malabsorption and food allergies?

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Jonathan LandsmanAbout the author: Jonathan Landsman is the host of NaturalHealth365.com, the NaturalHealth365 Talk Hour – a free, weekly health show and the NaturalHealth365 INNER CIRCLE – a monthly subscription to the brightest minds in natural health and healing.

Reaching hundreds of thousands of people, worldwide, as a personal health consultant, writer and radio talk show host – Jonathan has been educating the public on the health benefits of an organic (non-GMO) diet along with high-quality supplementation and healthy lifestyle habits including exercise and meditation.

References:

http://www.asm.org/index.php/journal-press-releases/93853-one-course-of-antibiotics-can-affect-diversity-of-microorganisms-in-the-gut

http://www.medicalnewstoday.com/articles/302179.php

http://www.naturalhealth365.com/gut-health-intestinal-flora-1448.html

http://www.naturalhealth365.com/side-effects-of-antibiotics-1620.html

 

http://www.naturalhealth365.com/antibiotic-gut-health-instestinal-flora-1690.html

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