One of the insurmountable problems with hormone replacement therapy is that when you replace a hormone you risk feeding the underlying glandular deficiency. In the exuberance associated with the idea of overcoming age-associated declines in sexual, cognitive, skeletal, cardiovascular, etc. function, with both synthetic and bioidentical hormones, the hormone replacement advocates have often neglected to educate their patients to several unintended, adverse effects of hormone replacement therapy (HRT): 1) the endocrine system has a negative feedback loop which guarantees that with time the body’s ability to produce adequate quantities of the very hormones being targeted for replacement will decline, resulting in the development of biological dependency on an external source of hormones — not exactly a picture of empowerment. 2) increasing levels of the target hormones will also result in increased production and possible accumulation of hormone metabolites with potentially toxic, as well as carcinogenic effects, e.g. estradiol turns to 16-hyroxylestrone, a potential carcinogen. While these risks may be outweighed by the benefits, and many of these risks can be reduced through dietary and supplemental regimes and plenty of vigilant clinical surveillance, the point is that HRT is not without its problems and limitations. Which brings us to an entirely different approach (one, no doubt, used for thousands of years), using foods and spices as our medicine….
Bioidentical Hormones
Despite large pay outs to victims, Pfizer keeps selling the hormone replacement drug and the government keeps trying to make sure there’s no competition from the natural alternative! 
Scientists at the University of California Riverside and Los Angeles report that a combination of vitamin D3 and a synthetic form of curcumin could help remove amyloid beta from the brains of 