How Cancer Cells Rewire Their Metabolism to Survive

Live Stronger. Live Longer.

Sanford-Burnham researchers discover that tumors lacking the protein PKCz are good at surviving when nutrients are scarce-opening a new therapeutic avenue that targets cancer metabolism

LA JOLLA, Calif., January 31, 2013 – Cancer cells need food to survive and grow. They’re very good at getting it, too, even when nutrients are scarce. Many scientists have tried killing cancer cells by taking away their favorite food, a sugar called glucose. Unfortunately, this treatment approach not only fails to work, it backfires-glucose-starved tumors actually get more aggressive. In a study published January 31 in the journal Cell, researchers at Sanford-Burnham Medical Research Institute discovered that a protein called PKCζ is responsible for this paradox. The research suggests that glucose depletion therapies might work against tumors as long as the cancer cells are producing PKCζ. (more…)

Cancer & Sugar

Strategy for Selective Starvation of Cancer Cells

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According to researchers at the University of California, San Francisco, sugar poses a health risk—contributing to around 35 million deaths globally each year. So high is its toxicity that it should now be considered a potentially toxic substance like alcohol and tobacco. Its link with the onset of diabetes is such that punitive regulations, such as a tax on all foods and drinks that contain “added’’ sugar, are now warranted, the researchers concluded. They also recommend banning sales in or near schools, as well as placing age limits on the sale of such products. (more…)

Researchers Discover Type III Diabetes

 brain31 300x233 Researchers Discover Type III Diabetes(Health Secrets Newsletter) Groundbreaking research from Rhode Island on the causes of Alzheimer’s disease has discovered this degenerative brain condition is actually another type of diabetes — Type III. Until now most treatments for this form of dementia have been largely ineffective and centered on getting rid of symptoms. This research has opened a new avenue of treatment that suggests the potential for restoring of normal brain function.
The Rhode Island Hospital research team, lead by Suzanne de la Monte, M.D., found a link between brain insulin resistance (diabetes) and other key mediators of neuronal injury that speed the development of Alzheimer’s. They found that when Alzheimer’s is established, therapeutic efforts must work to reduce toxins production in the brain.
These conclusions come after a decade of research by Dr. de la Monte with this and other research teams. Each step of the way has produced more clinical and experimental evidence that treatment with insulin or insulin sensitizer agents such as insulin growth factor (IGF) can enhance cognitive function and in some circumstances slow the rate of cognitive decline in Alzheimer’s patients. (more…)

Alzheimer’s Is Diabetes of the Brain: Diet & Vaccination Connections

Alzheimer’s can be prevented. Why waste your last years and put both emotional and financial stress on your family, when you could be living life to the hilt?
Woman, elderly, sad

by Heidi Stevenson

The now-traditional belief that Alzheimer’s disease is caused by a buildup of plaques on the brain has always been deficient for one simple reason: It completely ignores why those plaques build up. We now have good information that documents the reason for it. Alzheimer’s shares its genesis with diabetes. It’s a derangement of the body’s ability to process or produce insulin. Alzheimer’s is a third type of diabetes: type 3. (more…)

Insulin, Leptin, and Blood Sugar – Why Diabetic Medication Fails

Type 2 diabetes is a difficult metabolic problem. It is a national embarrassment that so many of our young people are becoming type 2 diabetic. It is a national disgrace that millions of type 2 diabetic patients are being injured with commonly used diabetic medications that are known to make their metabolic situation worse.  (more…)

Have you ever wondered how your body actually burns fat?

Years ago a popular health magazine decided to try to answer that same question with a novel approach. They looked at how people actually gain weight, reasoning that if we knew all the “tricks” to gaining weight, we could learn what not to do if we wanted to stay lean.

So they followed around a bunch of Sumo wrestlers whose job requires them to maintain enormous stores of body fat. Whatever it is they were doing, that’s exactly what we shouldn’t do.

Now Sumo wrestlers gain weight for a number of reasons, and genetics certainly plays a role, but what they did eating-wise is the thing we want to pay attention to, because it’s ultimately going to teach us something about how to burn fat. (more…)

We Really Can Make Glucose From Fatty Acids After All! O Textbook, How Thy Biochemistry Hast Deceived Me!

Biochemistry textbooks generally tell us that we can’t turn fatty acids into glucose.  For example, on page 634 of the 2006 and 2008 editions of Biochemistry by Berg, Tymoczko, and Stryer, we find the following:

Animals Cannot Convert Fatty Acids to Glucose

It is important to note that animals are unable to effect the net synthesis of glucose from fatty acids.  Specficially, acetyl CoA cannot be converted into pyruvate or oxaloacetate in animals. (more…)

HFCS explained: Here’s why it’s far more dangerous to your health than table sugar

High-fructose corn syrup (HFCS) is a popular sweetener because it is chemically different from sugar — it has a longer shelf life and mixes better into beverages. Yet the corn industry likes to downplay these differences, pointing out that sugar is 50 percent fructose and 50 percent glucose, while HFCS is 55 percent fructose and 45 percent glucose. (more…)