Is Ibuprofen As Deadly As Vioxx?

Is Ibuprofen As Deadly As Vioxx?

Our medicalized approach to pain may be putting us in harms way.   However, there are safe, natural approaches that can ease painful conditions.

How Coxibs Killed Tens of Thousands

Non-steroidal anti-inflammatory drugs (NSAIDs), which include over-the-counter pharmaceuticals such as ibuprofen, naproxen, and aspirin, rank among the most widely used pharmaceuticals worldwide. Their chief mechanism of action is inhibition of two forms of cyclo-oxygenase (COX), namely COX-1 and COX-2 (1). Also known as prostaglandin-endoperoxide synthase (PTGS), COX is responsible for the production of downstream mediators of pain and inflammation, such as thromboxane and prostaglandins. Due to their suppression of prostaglandins, which exert protective roles in the gastrointestinal tract, one of the most frequent adverse effects of NSAIDs is irritation of the gastric mucosa.

Thus, newer generation selective COX-2 drugs, known as the coxibs, were introduced in the 1990s to mitigate the risk of peptic ulceration that results from COX-1 suppression. By 2004, coxibs had dominated the prescription drug market for NSAIDs, with worldwide sales of approximately $10 billion (2). Their development was based on the premise that COX-1 was the source of the cytoprotective prostaglandins in the gastric epithelium, whereas COX-2 was the source of the inflammatory mediators, prostaglandins E2 and I2 (2). However, as early as 1999, scientists had reported that coxibs inhibit generation of prostaglandin I2, the primary product of COX in the endothelium, responsible for reducing platelet aggregation and proliferation of vascular smooth muscle cells and for inducing vascular vasodilation (2).

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Ibuprofen Can Stop Your Heart (31% Increase In Cardiac Arrest Risk)

Ibuprofen Can Stop Your Heart (31% Increase In Cardiac Arrest Risk)

A new study reveals that a commonly consumed painkiller, wrongly considered “harmless” by millions, is probably causing thousands of deaths from cardiac arrest each year.

According to the Sudden Cardiac Arrest Foundation, sudden cardiac arrest (SCA) is a leading cause of death among adults over 40 in the United States and other countries, with about 326,200 people experiencing an out-of-hospital SCA each year in the US alone; nine of 10 victims of SCA will die.1

Suprisingly, however, the causes of SCA are still widely considered unknown. Instead, the medical profession opts for pointing the finger at vague risk factors, such as family history, previous heart problems, or elevated LDL cholesterol (a long debunked surrogate marker for heart disease].

But what if something so obvious and preventable as the consumption of NSAID drugs could be contributing to this health epidemic?

New Study Reveals Heart-Stopping Side Effects of NSAIDs

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Ibuprofen Kills Thousands Each Year, So What Is The Alternative?

Ibuprofen Kills Thousands Each Year, So What Is The Alternative?

A recent Reuters’ article opened with the following stunning sentence:

“Long-term high-dose use of painkillers such as ibuprofen or diclofenac is ‘equally hazardous’ in terms of heart attack risk as use of the drug Vioxx, which was withdrawn due to its potential dangers, researchers said.”  

The 2004 Vioxx recall, as you may remember, was spurred by the nearly 30,000 excess cases of heart attacks and sudden cardiac deaths caused by the drug between 1999-2003. Despite the fact that scientific research had accumulated as early as 2000 linking Vioxx to increased heart attacks and strokes, the drug’s manufacturer Merck, and the FDA, remained silent as the death toll steadily increased. (more…)