Clinical Efficacy of Systemic Enzyme Support

Clinical observations and literature review both affirm the conviction that providing “systemic enzyme support,” using Wobenzym N or Wobenzym PS, is an essential component in successfully managing inflammation disorders and other conditions with immune system dysregulation.

In addition to improving clinical outcomes in conditions with overt inflammation, such as rheumatoid arthritis, thrombophlebitis, pyelonephritis, prostatitis, and psoriasis, systemic enzyme support is also effective in conditions with covert inflammation, such as osteoarthritis, angina, atherosclerosis, myocardial infarctions, and diabetes, to name a few. The adjuvant properties of systemic enzyme support have also been observed and documented for a number of cases including adnexitis, arthritis, papillomas and various forms of cancer. This article will familiarize clinicians with the therapeutic benefits of systemic enzyme support and review pertinent findings related to this treatment.  (more…)

Horse Chestnut Update: Weight Management and Brain Health

Horse chestnut and its active compound called aescin (also escin) is best known for its ability to correct vein-related circulatory problems and leg swelling.  It has been used historically1 for hemorrhoids, kidney stones, fever, GI tract support, bladder problems, post-operative edema, and skin problems.  New studies show that it may also be helpful for weight management and brain health – while helping to boost antioxidant function and reducing inflammation.

Researchers fed mice a high fat diet for five weeks, resulting in significantly elevated leptin and total cholesterol.  Feeding the mice horse chestnut at the same time as consuming a high fat diet resulted in 31% less rise in leptin2 and a 17% increase in protective HDL Cholesterol High-density lipoprotein that is one of five lipoproteins that enable cholesterol and triglycerides to be transported within the bloodstream to the liver and to the adrenals, ovaries, or testes for the production of steroid hormones. .  Lowering leptin levels is important as that means it helps combat leptin resistance and consequent food cravings.  Another animal study showed that horse chestnut given with a high fat diet prevented adverse changes to the liver3 by boosting antioxidant glutathione levels in liver cells – the core antioxidant needed for cellular health.

In another recent study scientists induced stroke by occluding both carotid arteries into the brain.  Horse chestnut4 was given ½ hour after the stroke event and repeated daily for three days.  Tests then showed that horse chestnut significantly improved memory and learning while reducing damage to the hippocampus in the brain.  Analysis of gene responses showed that it reduced inflammatory gene signaling while boosting repair gene signaling.  The mechanisms of improvement suggest that horse chestnut may be a good nutrient for general brain health to help offset inflammatory brain stress.

The potent anti-inflammatory properties of horse chestnut were further demonstrated by researchers at the MD Anderson Cancer Center when they showed that horse chestnut could powerfully lower the primary gene signal, NF-kappaB, which is overly wound up in just about every type of cancer.  The reduction of NF-kappaB in resistant cancer cells now enabled the cancer cells to be killed by chemo drugs.

Collectively, this new information expands the usefulness of this very helpful circulatory compound.


Wednesday, December 08, 2010 –  Byron Richards, CCN

Referenced Studies:

  1. ^ Horse Chestnut Monograph Altern Med Rev.
  2. ^ Horse Chestnut Improves Leptin Status and HDL Cholesterol Pharm Biol.  Avci G, Küçükkurt I, Küpeli Akkol E, Yeşilada E.
  3. ^ Horse Chestnut Boosts Liver Antioxidant Status J Ethnopharmacol.  Küçükkurt I, Ince S, Keleş H, Akkol EK, Avci G, Yeşilada E, Bacak E
  4. ^ Horse Chestnut Protects Brain Following Stroke Neurochem Int.  Zhang L, Fu F, Zhang X, Zhu M, Wang T, Fan H.
  5. ^ Horse Chestnut Lowers Inflammatory NF-kappaB Mol Pharmacol.  Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB.