Is Ibuprofen As Deadly As Vioxx?

Is Ibuprofen As Deadly As Vioxx?

Our medicalized approach to pain may be putting us in harms way.   However, there are safe, natural approaches that can ease painful conditions.

How Coxibs Killed Tens of Thousands

Non-steroidal anti-inflammatory drugs (NSAIDs), which include over-the-counter pharmaceuticals such as ibuprofen, naproxen, and aspirin, rank among the most widely used pharmaceuticals worldwide. Their chief mechanism of action is inhibition of two forms of cyclo-oxygenase (COX), namely COX-1 and COX-2 (1). Also known as prostaglandin-endoperoxide synthase (PTGS), COX is responsible for the production of downstream mediators of pain and inflammation, such as thromboxane and prostaglandins. Due to their suppression of prostaglandins, which exert protective roles in the gastrointestinal tract, one of the most frequent adverse effects of NSAIDs is irritation of the gastric mucosa.

Thus, newer generation selective COX-2 drugs, known as the coxibs, were introduced in the 1990s to mitigate the risk of peptic ulceration that results from COX-1 suppression. By 2004, coxibs had dominated the prescription drug market for NSAIDs, with worldwide sales of approximately $10 billion (2). Their development was based on the premise that COX-1 was the source of the cytoprotective prostaglandins in the gastric epithelium, whereas COX-2 was the source of the inflammatory mediators, prostaglandins E2 and I2 (2). However, as early as 1999, scientists had reported that coxibs inhibit generation of prostaglandin I2, the primary product of COX in the endothelium, responsible for reducing platelet aggregation and proliferation of vascular smooth muscle cells and for inducing vascular vasodilation (2).

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Top 10 Reasons to Eat Your Cruciferous Veggies

10 Reasons to Eat Your Cruciferous Vegetables

Top 10 Reasons to Eat Your Cruciferous Veggies

Everyone knows that eating vegetables has profound health benefits. But, like all foods, not all vegetables are created the same. Some are better than others in terms of nutritional content, and overall contribution to vibrant health. If you look more closely at their phytochemical [plant-based chemical] content, or the growing amount of research into their specific effects on the body and disease, a few vegetables appear to be downright “miracle” foods!

One such group of veggies are those of the Brassica family; commonly known as cruciferous. These include broccoli, brussel sprouts, cabbage, cauliflower, kale, radish, rutabaga, turnip and even arugula.

What makes this group of veggies so special? Sulforaphane.

Sulforaphane is a phytochemical abundant in cruciferous vegetables, and it’s been getting a ton of attention from researchers. But it all starts with glucoraphanin.

Sulforaphane is produced when the enzyme myrosinase converts glucoraphanin, a glucosinolate (natural compound found in some plants), through a chemical reaction induced by damage to the plant, such as cutting or chewing. As such, glucoraphanin is known as the precursor to sulforaphane.

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Worth Repeating: Marijuana Is One of the Best-Studied Medicines In History

Ben Whalley, middle, with Dr Gary Stephens and Dr Claire Williams of Reading University at a secret cannabis farm in the south of England in the hope of producing a new treatment for epilepsy [Geoff Pugh/The Telegraph]

Ben Whalley, middle, with Dr Gary Stephens and Dr Claire Williams of Reading University at a secret cannabis farm in the south of England in the hope of producing a new treatment for epilepsy
[Geoff Pugh/The Telegraph]

Editor’s note: Welcome to Room 420, where your instructor is Mr. Ron Marczyk and your subjects are wellness, disease prevention, self actualization, and chillin’.

An overwhelming amount of very promising research has been gathered supporting the use of medical cannabis for many illnesses and diseases… and the evidence is now impossible to ignore.

Examples:

WorthRepeatingLogo“The endogenous cannabinoid system has revealed potential avenues to treat many disease states … Medicinal indications of cannabinoid drugs including compounds that result in enhance endocannabinoid responses (EER) have expanded markedly in recent years.”

“The wide range of indications covers … chemotherapy complications, tumor growth, addiction, pain, multiple sclerosis, glaucoma, inflammation, eating disorders, age-related neurodegenerative disorders, as well as epileptic seizures, traumatic brain injury, cerebral ischemia, and other excitotoxic insults.”

Source: “Cannabinoid drugs and enhancement of endocannabinoid responses: strategies for a wide array of disease states,” Current Molecular Medicine, September 2006

and…

[NORML]

[NORML] (more…)

Study: Tree bark compound helps reduce severe pain symptoms naturally

A new study published in the journal Nature Chemistry provides new insight into the power of a rare type of tree bark to relieve serious pain. Scientists from the Scripps Research Institute (SRI) in Florida discovered that the bark of the Tabernaemontana divaricata plant, also known as crepe jasmine, contains a compound known as conolidine that appears to be just as effective at treating pain as morphine, but without all the harmful side effects. (more…)