Postcholecystectomy syndrome (PCS) refers the presence of symptoms after cholecystectomy (removal of the gallbladder). These symptoms can represent either the continuation of symptoms thought to be caused by the gallbladder or the development of new symptoms normally attributed to the gallbladder. Postcholecystectomy syndrome also includes the development of symptoms caused by removal of the gallbladder. Postcholecystectomy syndrome reportedly affects about 10% to 15% of patients who have had this surgery. This condition is caused by alterations in bile flow due to the loss of the reservoir function of the gallbladder. Due to this, two main groups may arise. On the one hand, because of continuously increased bile flow into the upper gastrointestinal (GI) tract, esophagitis and gastritis may result in nausea and indigestion. On the other hand, in the lower GI tract, there may be distention, flatulence, diarrhea, and colicky lower-abdominal pain. Generalized symptoms may also include fever and jaundice.
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