Pradaxa: Legal Mass Murder!

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A Promising Drug With a Flaw was the name of an article published in the New York Times this past week.

Dr. Bryan A. Cotton, a trauma surgeon in Houston, had not heard much about the new anticlotting drug Pradaxa other than the commercials he had seen during Sunday football games. Then people using Pradaxa started showing up in his emergency room. One man in his 70s fell at home and arrived at the hospital alert and talking. But he rapidly declined. “We pretty much threw the whole kitchen sink at him,” recalled Dr. Cotton, who works at Memorial Hermann-Texas Medical Center. “But he still bled to death on the table.” Unlike warfarin, an older drug, there is no antidote to reverse the blood-thinning effects of Pradaxa. “You feel helpless,” Dr. Cotton said. The drug has contributed to the bleeding deaths of at least eight patients at the hospital. “And that’s a very bad feeling for us.” Pradaxa has become a blockbuster drug in its two years on the market, bringing in more than $1 billion in sales for its maker, the privately held German drug maker Boehringer Ingelheim. (more…)

Anti-coagulant Pradaxa Boosts Cardiac Danger

Boehringer Ingelheim GmbH’s anti-coagulant Pradaxa increases a patient’s risk of heart attack or severe chest pain, according to a review of studies conducted on the drug.

An analysis of seven clinical trials found that it was “significantly associated with a higher risk” of heart attacks and acute coronary syndrome, or ACS, a designation that includes heart attacks and chest pain, researchers wrote in a report published today in the Archives of Internal Medicine. (more…)